EPO has been safely used for prevent preterm anemia and recent studies have shown the
neuroprotective effect. Our hypothesis is that EPO could prevent preterm brain injury. The
aims of this study include: to investigate the safety and efficacy of EPO by using 500u/kg
higher than the dose of anemia treatment (250u/kg); to evaluate the effect of EPO on
neurodevelopment in preterm infants; to detect biological indicators and explore the
neuroprotective mechanism of EPO.