Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery

• Status: Completed
• Trial end date: 2008-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine if morphine administered by bolus before initiating Remifentanil by infusion decreases the incidence of acute post-operative opioid tolerance as demonstrated by decreased post - operative morphine consumption in children undergoing scoliosis surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Hospital for Sick Children
• Treatments: Morphine

Criteria

Inclusion Criteria:

• Unpremedicated

• ASA physical status 1 or 2

• Aged 11 - 18

• Scheduled to undergo posterior instrumentation for correction of idiopathic scoliosis

Exclusion Criteria:

• Chronic opioid use within three months prior to surgery

• Inability to self-administer morphine using a patient-controlled analgesia (PCA) device

• Elective postoperative ventilation

• Obesity (> 130% ideal body weight)

• Known sensitivity to morphine, remifentanil or any other agent within the standardized protocol

• Failure to obtain written consent or assent