Effect of EGF With Silver Sulfadiazine Cream Compared With Silver Zinc Sulfadiazine Cream for Treatment of Burn Wound
Status:
Completed
Trial end date:
2012-05-01
Target enrollment:
Participant gender:
Summary
Partial thickness burn wounds are most likely to heal within 2-3 weeks mainly by mechanism of
epithelialization. However, it depends on the depth of the wounds and patient condition.
Infection is one of the most common complications causing delay in wound healing which might
affect to quality of patient's life. Generally, the standard treatment of partial thickness
burn wound is topical 1% silver sulfadiazine cream. Previous studies had been reported the
broad spectrum antimicrobial activity of silver sulfadiazine cream but it did not demonstrate
the accelerating effect of wound healing. Therefore, the combination of substance which can
promote wound healing to topical silver sulfadiazine cream might benefit for partial
thickness burn wound treatment.
The objective of this study was to compare the results of partial thickness burn wound
treatment at burn unit, Siriraj hospital with topical cream containing 1% silver sulfadiazine
plus 6% epidermal growth factor (EGF) and 1% silver zinc sulfadiazine. The demographic data
(age, sex, %body surface area burn), time of wound closure, pain and itching, dose and type
of pain and itching medication, adverse effect of topical medication, some laboratory results
and cost of expenses.
This is the prospective, double blinded, randomize-controlled study. The sample sizes were
partial thickness burn wound patients who were treated at burn unit, Siriraj hospital.
Patients were allocated into 2 groups receiving treatment with either topical silver
sulfadiazine plus EGF or silver zinc sulfadiazine. All parameter data were analyzed with
repeated measure ANOVA and independent t-test.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Chulalongkorn University
Collaborator:
National Science and Technology Development Agency, Thailand