Effect of Dipeptidyl Peptidase-IV Inhibitor and Sulfonylurea on Glucose Variability and Oxidative Stress

• Status: Unknown status
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This research will focus on the effect of Sitagliptin on 24 hour glycemic excursion and improvement of oxidative stress markers compared to long acting sulphonylurea Glimepiride in type 2 diabetic patients with inadequate glycemic control on metformin

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Catholic University of Korea
• Collaborator: MSD Korea Ltd.
• Treatments: Dipeptidyl-Peptidase IV Inhibitors; Glimepiride; Sitagliptin Phosphate

Criteria

Inclusion Criteria:

• patients with type 2 diabetes

• duration of diabetes less than 10 years

• HbA1c 6.5-8.0%

• BMI 20-30

• on stable dose of metformin (more than 1000mg) for at least 2 months

Exclusion Criteria:

• having oral hypoglycemic agents other than metformin

• using insulin

• serum creatinin >= 1.5 mg/dL

• SGOT, SGPT >= 90

• ischemic heart disease

• congestive heart failure (NYHA class >=2)

• severe diabetic complication (PDR, CRF, CVA)

• on medication affecting glucose profile (such as steroid)

• infectious disease

• malignancy

• pregnant or breast-feeding woman