Overview

Effect of Different Intravenous Fluids on Post-operative Chronic Subdural Hematoma Size and Recurrence

Status:
Recruiting
Trial end date:
2022-06-01
Target enrollment:
0
Participant gender:
All
Summary
This study aims to reduce the recurrence rate of chronic subdural hematomas (CSDH) by manipulating the post-operative intravenous fluid use. The hypothesis relies on the relationship between osmolality and volume changes related to osmolality. We will be administering dextrose 5% in 1/4 normal saline (D5 1/4NS) post-operatively to induce brain expansion which can take up the residual CSDH space, to help reduce recurrence rate.
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Carilion Clinic
Criteria
Inclusion Criteria:

- Diagnosis of chronic subdural hematoma (based on imaging)

- Need for surgical intervention (assessed by attending neurosurgeon based on full
neurological assessment)

- The procedure of choice is burr hole drainage

- Cessation of anti-coagulant therapy with accompanying normal lab values in appropriate
time frames respective to the drug

- Tolerance of supine position

Exclusion Criteria:

- <60 years old

- Presence of acute hemorrhage, stroke, or parenchymal damage

- Neurological deficits not accountable to mass effect

- Hyponatremia or inherent electrolyte imbalances

- Pregnancy or non-consentable patients

- Previous neurological surgery up to 1 year before being considered for the study

- Rapid re-expansion of brain observed intraoperatively by attending neurosurgeon

- Congestive heart failure or other medical conditions precluding normal postoperative
administration of IV fluids

- Blood glucose levels > 135 mg/dL