Effect of Different Dialysis Dosage on Prognosis in Maintenance Peritoneal Dialysis Patients
Status:
Completed
Trial end date:
2012-07-01
Target enrollment:
Participant gender:
Summary
Peritoneal dialysis (PD) is an important model of renal replacement therapy for end-stage
renal disease (ESRD) patients. Thus far, evidence for the initiation dosage of PD treatment
is lacking, most patients begin their PD with four 2 L exchanges per day. However, many
patients have their residual renal function at the initiation of PD, an 8 L dialysate per day
will enhance the toxicity of bioincompatible dialysate and increase the economic burden
compared with that of 6 L dialysate per day. Thus, the investigators perform a prospective,
randomized, controlled, multi-center clinical study. The patients initiation of PD treatment
within 6 months are randomized to be assigned to two groups: 6 L of dialysate per day and 8 L
of dialysate per day, follow up will be regularly performed until 96 weeks. Clinical outcomes
such as mortality, complications and life quality between the two groups will be
investigated.