Effect of Different Antihypertensive Drugs on Central Blood Pressure
Status:
Active, not recruiting
Trial end date:
2026-03-01
Target enrollment:
Participant gender:
Summary
Trial name) The differential effects of antihypertensive drugs on central blood pressure:
comparison between beta-blocker(BB) and angiotensin receptor blocker ARB)
Objectives) To evaluate the effect of BB, which has vasodilatory effects, on CBP by
comparison between ARB, one of the most widely used class of antihypertensives.
Study design) A multicenter, prospective, randomized, controlled, open-label clinical trial
for hypertension patients.
Patient enrollment) 110 patients will be enrolled at 2 centers in South Korea.
Patient follow-up) Patients will go through an initial washout period of two weeks prior to
randomization. After pre-medication baseline visit and randomization, clinical follow-up will
occur at 4, 8, 12 weeks after initial administration of randomized drug. The follow-up visits
are office visits.
Primary endpoint) Reduction in CBP at 12 weeks.
Secondary endpoints) Clinical events including adverse reactions to the drugs.