Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients
Status:
Unknown status
Trial end date:
2018-04-01
Target enrollment:
Participant gender:
Summary
Septic shock is one of the major causes of death worldwide with in-hospital mortality rates
varying between (11.9% to 47.2 %). Alterations in microcirculatory blood flow were associated
with high risk of organ dysfunction and death. Experimental studies on septic rats revealed
that dexmedetomidine treatment can effectively reduce the generation of inflammatory
mediators and yields beneficial effects on endotoxemic animals' microcirculation.