Effect of Dexmedetomidine on Pain Due to Propofol Injection
Status:
Unknown status
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
Propofol is commonly used IV anesthetic, it has been formulated in a concentration of 10
mg/ml in a fat emulsion consisting of 10% soybean oil (long-chain triglycerides). When used
for anesthetic induction, propofol causes pain on injection in 28%-90% of patients. pain
probably results from a direct irritant effect. Several methods have been used to reduce this
pain. Lidocaine pretreatment has been commonly proposed to decrease propofol induced pain,
but its failure rate is between 13-32%. Dexmedetomidine is highly selective alfa-2
adrenoreceptor agonist. Alpha-2 receptors are located on blood vessels where they inhibit
norepinephrine release. Investigators, therefore, speculated that dexmedetomidine could
attenuate the pain due to injection of propofol. Investigators conducted a study to determine
the efficacy of dexmedetomidine in decreasing pain due to injection of propofol.