Overview

Effect of Dexmedetomidine on Pain Due to Propofol Injection

Status:
Unknown status
Trial end date:
2011-10-01
Target enrollment:
0
Participant gender:
All
Summary
Propofol is commonly used IV anesthetic, it has been formulated in a concentration of 10 mg/ml in a fat emulsion consisting of 10% soybean oil (long-chain triglycerides). When used for anesthetic induction, propofol causes pain on injection in 28%-90% of patients. pain probably results from a direct irritant effect. Several methods have been used to reduce this pain. Lidocaine pretreatment has been commonly proposed to decrease propofol induced pain, but its failure rate is between 13-32%. Dexmedetomidine is highly selective alfa-2 adrenoreceptor agonist. Alpha-2 receptors are located on blood vessels where they inhibit norepinephrine release. Investigators, therefore, speculated that dexmedetomidine could attenuate the pain due to injection of propofol. Investigators conducted a study to determine the efficacy of dexmedetomidine in decreasing pain due to injection of propofol.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
KVG Medical College and Hospital
Treatments:
Dexmedetomidine
Propofol
Criteria
Inclusion Criteria:

- ASA I & II

- Both gender

- Age 18-60

- Elective surgery

Exclusion Criteria:

- Patients taking sedatives or analgesics in the past 24 hours

- History of allergic reactions to anesthetic drugs,

- Atrio-ventricular conduction defects

- Cardiovascular disease and

- Pregnant