Overview

Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

Status:
Completed
Trial end date:
2017-07-31
Target enrollment:
0
Participant gender:
All
Summary
Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Yonsei University
Treatments:
Dexmedetomidine
Criteria
Inclusion Criteria:

- American Society Anesthesiologists classification I-III

Exclusion Criteria:

- use of antioxidants clinically significant cardiovascular, renal, or hepatic diseases
heart block greater than the first degree