Overview

Effect of Deep Neuromuscular Block (NMB), Inhalation or TIVA on Pneumoperitoneum.

Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
0
Participant gender:
All
Summary
The objective of this study is to compare the value of deep neuromuscular block (NMB) (using rocuronium) in laparoscopy versus high dose opioids (using remifentanil) or 1 minimum alveolar concentration (MAC) inhalation (using sevoflurane) for the surgeon. The study hypothesis is that laparoscopic workspace is larger when using rocuronium versus opioids or inhalation. Laparoscopic workspace is measured as the abdominal compliance and the pressure at volume zero (PV0) using the abdominal pressure volume relation. Three points allow to calculate the abdominal compliance and the pressure at zero volume (PV0).
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
AZ Sint-Jan AV
Treatments:
Remifentanil
Rocuronium
Sevoflurane
Criteria
Inclusion Criteria:

1. Laparoscopic bariatric surgery in a patient older than 18 years of age without previous
laparotomy. Examples of laparoscopic bariatric procedures are gastric band, sleeve
gastrectomy, gastric bypass, gastric bypass after lap band, and revision of a gastric
bypass

Exclusion Criteria:

1. Allergies or contraindications to the use of one or more of the following drugs:
propofol, rocuronium, sugammadex, remifentanyl, or sevoflurane

2. History of a laparotomy

3. Emergency laparoscopy