Overview

Effect of DPP4 Inhibition on Vasoconstriction

Status:
Completed
Trial end date:
2017-09-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to understand how dipeptidyl peptidase IV (DPP4) inhibition in diabetics affects hemodynamic parameters and sympathetic activation in the setting of increasing concentrations of neuropeptide Y, an endogenous peptide. The central hypothesis is that DPP4 inhibition decreases degradation of neuropeptide Y, resulting in increased vasoconstriction and sympathetic activation.
Phase:
Phase 4
Details
Lead Sponsor:
Vanderbilt University
Treatments:
Angiotensin-Converting Enzyme Inhibitors
Dipeptidyl-Peptidase IV Inhibitors
Enalapril
Enalaprilat
Sitagliptin Phosphate
Valsartan