Effect of Cortisol on Physical Exertion in Patients With Primary Adrenal Failure
Status:
Unknown status
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
The conventional glucocorticoid replacement therapy in primary adrenal insufficiency-
Addison's disease,renders the cortisol levels unphysiological, which may cause symptoms and
long-term complications. Many patients take stress-doses that are extra doses of
hydrocortisone or cortisone acetate before or during stressful physical or psychological
events. However, the effect of such dosing has not been tested in scientific studies. In this
double blind cross-over designed pilot trial we aim to test the effect of an extra dose of
cortisol on physical activity and hormone levels.