Effect of Copanlisib on Metformin Pharmacokinetics and Pharmacodynamics
Status:
Completed
Trial end date:
2019-02-12
Target enrollment:
Participant gender:
Summary
The purpose of this study is to learn about a drug-drug interaction. When two medications are
taken together at the same time, one medication may change the activity of the other
medication in the body - this is called a drug-drug interaction. This study is looking at the
effect the Bayer study drug, copanlisib, has on metformin, a commonly used medication to
treat diabetes. During the study, blood and urine samples will be collected and analyzed to
learn about pharmacokinetics (how copanlisib changes metformin levels in the body) and
pharmacodynamics (the effect metformin has on the body when taken together with copanlisib)
when someone takes both copanlisib and metformin together.