Effect of Colchicine on the Incidence of Atrial Fibrillation in Open Heart Surgery Patients

• Status: Completed
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the role of colchicine in the prevention of atrial fibrillation in patients undergoing open heart surgery. Half of participants will receive colchicine and the other half will not

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jordan Collaborating Cardiology Group
• Treatments: Colchicine

Criteria

Inclusion Criteria:

• All consecutive adult patients undergoing elective cardiac surgery

Exclusion Criteria:

• Documented history of AF or supraventricular arrhythmia or, absence of sinus rhythm on hospital admission

• Known severe liver disease or current transaminases >1.5 times the upper normal limit

• Current serum creatinine >2.5 mg/dl

• Known myopathy or elevated baseline preoperative creatine kinase

• Known blood dyscrasias

• Significant gastrointestinal disease

• Pregnant and lactating women

• Known hypersensitivity to colchicine

• Current treatment with colchicine for any indications

• Emergency surgery