Effect of Cock's Comb Extract in the Treatment of Arsenical Skin Lesion

• Status: Completed
• Trial end date: 2018-01-31
• Target enrollment: 0
• Participant gender: All

Summary

Cock's comb extract is rich in hyaluronic acid, which is used as viscosupplementation injection and oral supplementation for osteoarthritis. Hyaluronic acid acts as humectants and topical moisturizing agent to the skin due to excellent moisturizing property. It has anti-inflammatory effect and used in the treatment of ulcer healing and to reduce the intensity of radioepithelitis. It is also used as a topical vehicle for the delivery of drug to the skin in actinic keratosis. In the case of arsenical keratotic nodule, topical application of hyaluronic acid may tends to decrease keratosis by repeated hydration of the skin. Therefore, the study will be conducted to determine any beneficial effect of topical application of cock's comb extract in the treatment of the patients with severe palmar arsenical keratosis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Criteria

Inclusion Criteria: (Patients)

• Age: 18-60 years

• Sex: Both male and female

• Arsenical keratosis: Presence of severe keratosis (>5mm) in both palms

• Drinking arsenic contaminated water (>50 µg/L) for at least more than 6 months

• Patient voluntarily agreed to participate

• Patient who understood the instruction of applying drug and could apply drug as per as instruction

Exclusion Criteria:

• Age <18 and >60 years

• Pregnant and nursing mother

• Palmar psoriasis

• Eczema

• Any kind of systemic disease, inflammatory disease and infectious condition that affect skin for example diabetes mellitus, rheumatoid arthritis, systemic lupus erythrematosus, hepatitis

• Hypersensitivity to avain protein

• Malignancy

• Impaired renal function - if creatinine level >1.3 mg/dl incase of men and >1.1 mg/dl in case of women

• Patient who received any treatment of arsenicosis within last three months