Effect of Coca-Cola on Iron Absorption

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this project is to measure the effect of Coca-Cola and Diet Coke, relative to mineral water, on non-haem iron absorption. The results from this study will quantify any enhancing effect of Coca-Cola or Diet Coke on non-haem iron absorption and will be of use to the Coca-Cola Company and the scientific and nutrition community in evaluating the nutritional value of these products.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Institute of Food Research; Quadram Institute Bioscience
• Collaborators: The Coca-Cola Company; University of East Anglia

Criteria

Inclusion Criteria:

• Women

• Age > 18 and < 65

Exclusion Criteria:

• Men

• Age < 18 or > 65

• BMI <18.5 or > 35

• Serum ferritin value of <12 or >50µg/L (±10% to allow for day to day and analytical variation)

• Volunteers will be excluded if they are found to have depressed or elevated blood pressure measurements (<90/50 or <95/55 if symptomatic or >160/100)

• Diagnosed with a long-term illness requiring active treatment, e.g. diabetes, cancer, cardiovascular disease.

• Gastrointestinal disease (excluding hiatus hernia unless symptomatic or study intervention/procedure is contraindicated)

• Regular prescribed medication that may interfere with iron metabolism

• Regular use of antacids and laxatives (at least once a week)

• Women who are pregnant or less than 12 months since giving birth

• Women breast feeding

• Vitamin supplements with or without minerals if taken more than once a week, and unwillingness to discontinue occasional use for the duration of study

• Unwillingness to discontinue use of herbal supplements for the duration of study

• Use of antibiotics within four weeks prior to study start

• Parallel participation in another study which involves dietary interventions or sampling of blood that may increase the volume taken above 500ml in a 4-month period

• Asthma requiring treatment within the last two years

• Results of clinical screening which indicate, or are judged by the HNU Medical Advisor to be indicative of a health problem which could compromise the well-being of the volunteer if they participated or which would affect the study data.

• Allergy to any of the ingredients in the test meals