Effect of Co-administration Lidocaine and Dexmedetomidine on Quality of Recovery
Status:
Completed
Trial end date:
2021-06-25
Target enrollment:
Participant gender:
Summary
BACKGROUND: Some studies have revealed that intravenous (IV) lidocaine or dexmedetomidine
might improve the quality of recovery undergoing laparoscopic surgery. The investigators
investigated whether co-administration lidocaine and dexmedetomidine could better improve the
the quality of recovery after laparoscopic total hysterectomy.
METHODS: One hundred and forty-four women with elective laparoscopic total hysterectomy were
randomly divided into four groups: Patients in group L received a bolus infusion of lidocaine
(2%; 1.5 mg/kg over 10 min before the induction of anesthesia), and then lidocaine was
infused at a rate of 1.5 mg/kg/h until close the pneumoperitoneum. Patients in group D
received a bolus infusion of dexmedetomidine (0.5 µg/kg over 10 min before the induction of
anesthesia), and then dexmedetomidine was infused at a rate of 0.4 μg/kg/h until close the
pneumoperitoneum. Patients in group LD received a bolus infusion of lidocaine (2%; 1.5 mg/kg)
and dexmedetomidine (0.5 µg/kg) over 10 min before the induction of anesthesia, and then
lidocaine and dexmedetomidine were infused at a rate of 1.5 mg/kg/h and 0.4 µg/kg/h until
close the pneumoperitoneum, respectively. Patients in group C received the same volume of
normal saline 10 min before the induction of anesthesia, and then normal saline (0.9%) was
continuously infused in an equal volume until close the pneumoperitoneum. Primary outcome was
the quality of recovery (QoR-40) at 1 day prior to sugery, 1 day after sugery, and 2 days
after sugery. The secondary outcomes included perioperative remifentanil consumption,
postoperative VAS scores, the incidence of postoperative nausea and vomiting, postoperative
rescue analgesics and anti-emetics, recovery time, extubation time, and Ramsay sedation scale
at 5 min, 10min, 30 min, 60 min after extubation.