Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
RATIONALE:
- Elevation in pulsatility indices (PIs), measured by transcranial Doppler (TCD), has been
postulated to reflect downstream increased vascular resistance caused by small-vessel
disease (SVD).
- Small arterial vessels are a significant determinant of vascular resistance and PIs are
elevated when SVD is present in the intracranial circulation.
- Cilostazol, a phosphodiesterase III inhibitor, has other non-antiplatelet effects, such
as vasodilation and neuroprotective effect. It has been shown to be effective in the
secondary prevention of stroke especially in the SVD and it may be related to the other
non-antiplatelet effects of cilostazol.
OBJECTIVES:
- In this study, we aim to investigate whether cilostazol affects the changes of PIs in
patients with acute lacunar infarction using serial TCDs.
- Our hypothesis is that cilostazol has other non-antiplatelet effects such as
vasodilation effect and may decrease the vascular resistance in patients with acute
lacunar infarction. Hence, cilostazol will decrease the PIs in patients with acute
lacunar infarction.