Effect of Chronic ACE and DPP4 Inhibition on Blood Pressure
Status:
Completed
Trial end date:
2020-08-01
Target enrollment:
Participant gender:
Summary
In this study the investigators will test the hypothesis that dipeptidyl peptidase IV (DPP4)
inhibition attenuates the antihypertensive effect of angiotensin-converting enzyme (ACE)
inhibition but not angiotensin receptor blockade or calcium channel blockade. The
investigators further hypothesize that this effect is mediated by substance P.