Effect of Chewing a Calcium Supplement Before Fluoride Rinse on Salivary Fluoride
Status:
Enrolling by invitation
Trial end date:
2022-01-31
Target enrollment:
Participant gender:
Summary
The anticaries effect of fluoride is through the increase in fluoride presence and retention
in the oral fluids, reducing dental demineralization and enhancing remineralization. Previous
studies showed that a preapplication of calcium (in a rinse) prior to administration of
fluoride greatly enhances fluoride concentration in the mouth and the anticaries effect of
fluoride. The hypothesis of this study is that the same can be achieved by chewing a calcium
supplement prior to a fluoride rinse. The first goal is to determine if chewing these calcium
supplements will increase calcium concentration in the oral fluids above baseline levels.
Secondly, the calcium supplement with the highest calcium release will be tested before a
fluoride rinse to assess the increased retention of fluoride in the oral fluids when compared
with the fluoride rinse alone. In both parts, healthy volunteers will participate and saliva
will be collected to assess calcium and fluoride concentration.