Effect of Centella Asiatica on Xerotic Skin in Diabetes Mellitus Type 2

• Status: Unknown status
• Trial end date: 2019-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to evaluate the effect of Centella asiatica on hydration status of lower leg skin of DM type 2 patients by measuring SRRC and Skin Capacitance in correlation with AGEs CML, inflammation marker IL-1α, and oxidative stress SOD in stratum corneum.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indonesia University
• Treatments: Petrolatum; Superoxide Dismutase

Criteria

Inclusion Criteria:

• Diagnosed with Diabetes Mellitus Type 2

• <60 years old by the end of the study

• suffered from dry skin on lower leg skin area, (minimum score= 3, measured using SRRC)

• agree to not use any skin care product orally or topically on lower leg skin and any other drugs (unless its part of diabetes mellitus management)

• normal ankle brachial index value ranged from 0.91-1.3

Exclusion Criteria:

• the presence of diabetic ulcer on one of patient's foot

• the presence of infection or dermatitis on the experimented foot

• the presence of severe inflammation on the experimented skin (redness score >2 or/and fissure score >2 measured by SRRC or/and total SRRC score ranged from12-16)

• estimated glomerular filtration rate value (eGFR) < 45

• impaired liver function (increased by 2x from upper limit reference for AST/ALT)