Effect of Carbamazepine and Oxcarbazepine on Serum Neuron-specific Enolase and S100B in Focal Seizures

• Status: Completed
• Trial end date: 2017-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The present study has been planned to assess the level of serum neuron-specific enolase (NSE) in focal seizures and its changes after antiepileptic therapy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: All India Institute of Medical Sciences, Bhubaneswar
• Treatments: Carbamazepine; Oxcarbazepine

Criteria

Inclusion Criteria:

• All patients with the clinical diagnosis of localization related epilepsy/focal seizure (International League Against Epilepsy 2010) with a history of an episode of seizure within 48 hours of presentation

• Treatment naïve patients or patients who had not taken any treatment for at least 3 weeks before inclusion.

Exclusion Criteria:

• History of any recent traumatic brain injury, cerebral ischemia/transient ischemic attack/stroke

• Patients with neuroendocrinal tumours

• History of any invasive neurosurgical /non-invasive neuropsychiatric procedure.

• Patients who are already under treatment for the presenting conditions.

• Medication history of psychoactive or central nervous system depressant drugs

• Pregnant and nursing women