Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
During clamping of one internal carotid artery for endarterectomy, blood flow through this
vessel has to be compensated by collateral arteries including the contralateral internal
artery and vertebral arteries. In 7 % of all patients undergoing carotid endarterectomy this
collateral flow is not sufficient to maintain adequate cerebral perfusion during clamping and
ischemic brain damage is likely to emerge. To maximize cerebral blood flow during clamping,
increase of blood pressure is a common procedure and routine at our institution. Increasing
blood pressure can be enabled by tapering a mixture of Cafedrine und Theodrenalin (Akrinor®)
until the designated blood pressure is reached. After declamping, the blood pressure has to
be reduced to normal values to avoid postoperative hyperperfusion syndrome. This is enabled
by tapering urapidil until normal blood pressure is achieved.
It has been shown that cerebral oxygenation measured by near infrared spectroscopy is reduced
by intravenous application of norepinephrine. Otherwise, intravenous nitroglycerine increases
cerebral oxygenation during cardiopulmonary bypass. Hence, cafedrine/theodrenalin and
urapidil may also have an effect on cerebral perfusion. In this prospective randomized study
the effect of cafedrine/theodrenalin and urapidil on cerebral oxygenation measured by near
infrared spectroscopy is investigated.
Phase:
N/A
Details
Lead Sponsor:
University Hospital Schleswig-Holstein University of Schleswig-Holstein