Effect of Cabergoline on Endometrial Vascularity During IntraCytoplasmic Sperm Injection

• Status: Unknown status
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine the effect of giving cabergoline to patients at risk of OHSS (ovarian hyperstimulation syndrome) after ovum pick up, on endometrial vascularity and it's effect on pregnancy outcome

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Kasr El Aini Hospital
• Treatments: Cabergoline

Criteria

Inclusion Criteria:

1. Age ≥18 - ≤40 years

2. Normal serum prolactin level.

3. Tubal factor of infertility.

4. Unexplained infertility.

5. BMI ≥ 30 kg/m2.

6. Estradiol (E2)>3,500 pg/ml on day of ovulation trigger.

7. Patients who underwent coasting for OHSS prevention.

8. More than 20 follicles ≥11 mm on the day of final oocyte maturation.

Exclusion criteria:

1. Contraindication of pregnancy e.g.: Somatic and mental diseases, which are contraindications for carrying of a pregnancy and childbirth, inborn malformations or acquired deformations of uterus cavity which make embryo implantation or carrying of a pregnancy impossible ,ovarian tumors.

2. Severe Male factor infertility.

3. Hyperprolactinemic patients.

4. Frozen embryo transfer cycles

5. Uterine Anomalies.

6. Uterine synechia.

7. History of Genital Tuberculosis.

8. Repeated implantation failure in ICSI.

9. On medication that is known to alter prolactin levels e.g antipsychotics, Atypical agents and risperidone

10. Thyroid dysfunction.

11. Medical disorders affecting serum prolactin eg acromegaly ,chronic renal failure and hypothyroidism