Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture
Status:
Terminated
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
Trauma and major operation are associated with an excessive inflammation reaction due to
tissue injury. This overwhelming immune response is considered to be a major risk factor in
the pathogenesis of late inflammatory complications such as acute respiratory distress
syndrome (ARDS), multiple organ dysfunction syndrome (MODS) and sepsis.
The investigators hypothesize that administration of C1-esterase inhibitor (C1-INH) will
attenuate the humane inflammatory response and, thereby, reduce the risk of inflammatory
complications due to surgical interventions in trauma patients with a femur or pelvic
fracture
Phase:
Phase 3
Details
Lead Sponsor:
UMC Utrecht
Collaborators:
Sanquin Sanquin Plasma Products BV
Treatments:
Complement C1 Inactivator Proteins Complement C1 Inhibitor Protein Complement C1s