Effect of Bupropion on Seizure Threshold in Depressed Patients
Status:
Completed
Trial end date:
2018-05-31
Target enrollment:
Participant gender:
Summary
The purpose of the study is to examine the effect of bupropion on seizure threshold and
duration in depressed patients receiving right unilateral ultra-brief electroconvulsive
therapy (ECT). The investigators plan to recruit 10 patients into the study, administer
sustained release (SR) bupropion 4 hours prior to receiving ECT. The investigators plan to
compare the seizure threshold and seizure durations between ECT sessions with and without
bupropion administration. The study's implication is to examine how ECT can be optimized by
rational combination with medications that lower seizure threshold.