Effect of Bisoprolol on Progression of Aortic Stenosis
Status:
Terminated
Trial end date:
2014-05-01
Target enrollment:
Participant gender:
Summary
Aortic stenosis has been thought to be a degenerative process basically induced by
long-lasting mechanical stress, and hemodynamic factors such as shear forces, acceleration of
blood flow, hypertension and rapid heart rate might contribute to progression of aortic
stenosis. Peak aortic jet velocity is known to be associated with clinical outcomes in mild
and moderate AS, and our previous study showed that rate of progression was significantly
associated with baseline aortic jet velocity in mild aortic stenosis. Because beta-blocker
therapy would decrease aortic jet velocity and heart rate, it might decrease hemodynamic
stress and eventually slow down the degenerative process in patients whose disease is not too
advanced for therapy to be effective. The investigators hypothesized that a beta-blocker
therapy would decrease the rate of progression of aortic stenosis by modifying hemodynamic
factors favorably in patients with mild to moderate aortic stenosis.