Overview

Effect of Benralizumab in Patients With Severe Nasal Polyps

Status:
Recruiting
Trial end date:
2020-07-01
Target enrollment:
400
Participant gender:
All
Summary
This is a randomized placebo controlled trial to evaluate the effect of benralizumab on people with severe nasal polyps.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Johns Hopkins University
Criteria
Inclusion Criteria:

- Age 18-75

- Severe bilateral nasal polyps (score 5 out of 8)

- SNOT-22 score > 30

- At least 70% compliance with inhaled nasal steroid based on daily diary

- Minimum weight of 40kg

- Negative pregnancy test for documented post menopausal for women

Exclusion Criteria:

- Any sinus surgery within the past 6 months