Effect of B-cell Depletion in Patients With Primary Sjögren's Syndrome
Status:
Completed
Trial end date:
2010-08-01
Target enrollment:
Participant gender:
Summary
The primary purpose of the study is to determine whether B-cell depletion with Rituximab has
an effect on the oral, ocular and general disease manifestations in patients with primary
Sjögren´s syndrome, that is, an effect on the symptoms of oral and ocular dryness,
improvement of the glandular function and a beneficial effect on the general symptoms such as
fatigue. The secondary purpose of the study is the investigate the underlying autoimmune and
pathophysiological mechanisms in Sjögren´s syndrome.