Effect of Astaxanthin in Moderate to Severe Knee Osteoarthritis
Status:
Recruiting
Trial end date:
2023-01-01
Target enrollment:
Participant gender:
Summary
This study will be 8 weeks randomized, double-blind, placebo-controlled trail to assess the
effect of astaxanthin in 80 moderate to severe knee osteoarthritis patients. Participants
will be assessed at baseline and after 8 weeks of intervention. Subjects will be randomized
to receive either astaxanthin 12 mg capsule daily or placebo capsule identical to astaxanthin
daily for 8 weeks. Evaluation of pain, stiffness and improvement of physical function will be
measured by WOMAC index before and after intervention. Inflammatory markers serum IL-6 and
hsCRP will be measured before and after intervention. Astaxanthin related adverse events will
be identified. Study outcome will establish safety and efficacy of astaxanthin in knee
osteoarthritis.
Phase:
Phase 2
Details
Lead Sponsor:
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh