Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis
Status:
Completed
Trial end date:
2018-04-28
Target enrollment:
Participant gender:
Summary
Periodontal disease is an immune-inflammatory disease which consists of connective tissue
breakdown, loss of attachment, and alveolar bone loss.In normal physiology, there is an
equilibrium maintained between reactive oxygen species (ROS) activity and antioxidant defence
capacity. when this equilibrium changes and shifts in favour of ROS, it will result in
oxidative stress (OS). Increased levels of acute phase proteins have been associated with
gingival inflammation and periodontitis, which reflected the locally stressed environment. it
has been well established that in chronic inflammation sites there is over-production of ROS.
The human body consists of an array of antioxidant defense mechanisms (non-enzymatic and
enzymatic antioxidants) which removes harmful ROS as soon as they are formed and prevent
their deleterious effects. Superoxide dismutase (SOD), catalase (CAT), and glutathione
peroxidase are the enzymatic antioxidants, while the nonenzymatic antioxidants include
vitamins E and C, and reduced glutathione. C - reactive protein (CRP) is a plasma protein
that reflects a measure of the acute phase response to inflammation and is one of the markers
of choice in monitoring this response. Changes in peripheral blood cellular and molecular
components can be seen in patients with periodontitis, as periodontitis includes inflammatory
changes of the periodontal tissues. Ashwagandha is also known as Indian ginseng and winter
cherry. It consists of dried roots of Withania Somnifera (Family: Solanaceae).6 The Sanskrit
words ashva meaning horse, and gandha meaning smell together form the name Ashwagandha.
Ashwagandha possessed marked anti-inflammatory effect against denaturation of protein in
vitro. the effect was plausibly due to the alkaloid and withanolide contents of ashwagandha.
It is a multipurpose herb, which acts as adaptogenic, antioxidant, anticancer, anxiolytic,
antidepressant, cardio protective, thyroid modulating, immunomodulating, antibacterial,
anti-inflammatory, neuroprotective, cognitive enhancing and hematopoietic agent.So, this
study is carried out to assess SOD & CRP levels with or without Ashwagandha supplementation
as an adjunct to scaling and root planing(SRP) in chronic periodontitis(CP) patients.