Effect of Apple Flavanols on Risk of Cardiovascular Disease
Status:
Completed
Trial end date:
2008-05-01
Target enrollment:
Participant gender:
Summary
A randomised three period cross over trial will be carried out in adults (19-64 years) to
assess the acute and chronic effects of a large dose of apple procyanidin (PA) compared with
a low dose of apple PA (negative control) and aspirin (positive control), on platelet
function and other risk factors of cardiovascular disease. Platelet function will be assessed
prior to a run in diet and at the start and end of each intervention. Volunteers will be
assigned at random to consume 230grams of low PA apple puree or high PA apple puree or
aspirin (75mg) each day for 2 weeks followed by a minimum 14 day wash out.
Hypothesis: Consuming apple PA reduces platelet function consistent with reduced risk of
cardiovascular disease.
Phase:
N/A
Details
Lead Sponsor:
Institute of Food Research Quadram Institute Bioscience