Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma

• Status: Terminated
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effect of antioxidant vitamins (vitamins C and E) on the development of coagulation derangements and nosocomial pneumonia after severe trauma in patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Alabama at Birmingham
• Treatments: alpha-Tocopherol; Antioxidants; Ascorbic Acid; Tocopherols; Tocotrienols; Vitamin E; Vitamins

Criteria

Inclusion Criteria:

• Adult trauma patients admitted to the emergency department at the University of Alabama at Birmingham (UAB) Hospital

• Blunt or penetrating injury

• UAB highest trauma activation

Exclusion Criteria:

• Age < 19 years of age

• Patients with known bleeding diathesis or who are concurrently taking anticoagulant medication

• Patients with known liver disease

• Minor patients

• Pregnant patients (known or suspected pregnancy)

• Patients who are incarcerated

• Patients who lack a surrogate