Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea

• Status: Completed
• Trial end date: 2017-02-14
• Target enrollment: 0
• Participant gender: All

Summary

The investigators investigated diastolic function among patients with obstructive sleep apnea (OSA) and hypertension stage I. In this randomized controlled trial, participants were randomly allocated to one of two groups: chlorthalidone associated with amiloride or amlodipine. Randomization was carried out prior to the start of the trial by an epidemiologist out of clinic and the randomization list was stratified by gender and severity of OSA. The research team and participants were blinded to the randomization list and allocation concealment was implemented. This trial aimed to detect changes in the echocardiography parameters with the drug treatment (higher in the intervention than in the placebo group). The investigators also assess change in daytime sleepiness among participants who already have been diagnosed with OSA.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital de Clinicas de Porto Alegre
• Treatments: Amiloride; Amlodipine; Antihypertensive Agents; Chlorthalidone

Criteria

Inclusion Criteria:

• Age 40 to 70 years

• Stage I hypertension (systolic BP: 140-159 or diastolic BP: 90-99 mmHg)

• No antihypertensive treatment or use of one antihypertensive drug

• Apnea / hypopnea index: 10 to 49 AH / hour

Exclusion Criteria:

• Low life expectancy

• Indication for use of calcium channel blockers or diuretics

• Allergy medications study

• Heart failure

• Myocardial infarction

• Recent stroke (last 3 months)

• Secondary hypertension

• Participation in another clinical trial (last 6 months)

• Pregnant women