Effect of Antibiotics on Urinary Microbiome

• Status: Withdrawn
• Trial end date: 2026-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Planning to study urine microbiota at baseline and after administration of bactrim antibiotics in healthy volunteers. Will intermittently collect voided urine specimens for 16 s DNA analysis over a period of 6 months after 2 weeks of bactrim or placebo.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Johns Hopkins University
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Criteria

Exclusion Criteria:

• Diagnosed or suspected urinary tract infection in prior 6 months

• Treated with antibiotics for any reason in prior 6 months

• Allergy to sulfa

• Under 18

• Pregnant or planning to become pregnant in the next 12 months by self report (as is the clinical standard for prescribing this medication for suspected or proven UTI treatment)

• Use indwelling or intermittent urinary hardware or implant such as supra-pubic tube or catheter

• Neurogenic bladder

• Baseline renal insufficiency

• Glucose-6-phosphate dehydrogenase deficiency

• Taking angiotensin converting enzyme

• Angiotensin receptor blocker

• Nursing

• HIV/AIDS

• On Immunosuppressant drugs

• On Chemotherapy/Immunotherapy

• Liver dysfunction

• On the following medications: DOFETILIDE, METHENAMINE & LEVOMETHADYL; WARFARIN & Methotrexate; GEMIFLOXACIN, DIGOXIN, PYRIMETHAMINE, CLASS IA ANTIARRHYTHMIC AGENTS (Quinidine, procainamide, disopyramide), TRICYCLIC ANTIDEPRESSANTS (amitriptyline, desipramine, doxepin, Imipramine, nortriptyline, amoxapine, clomipramine, maprotiline, trimipramine, and protriptyline), LEUCOVORIN CALCIUM.