Effect of Antibiotics on Penile Microbiome and HIV Susceptibility Study in Ugandan Men

• Status: Unknown status
• Trial end date: 2019-12-07
• Target enrollment: 0
• Participant gender: All

Summary

This pilot study will assess the impact of four antimicrobial products (3 topical, one systemic) on the foreskin microbiome and HIV susceptibility of foreskin-derived CD4+ T cells. Participants will include HIV-uninfected Ugandan men presenting for elective male circumcision to reduce their HIV risk.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Toronto
• Collaborators: Entebbe General Hospital; UVRI-IAVI HIV Vaccine Program
• Treatments: Clindamycin; Clindamycin palmitate; Clindamycin phosphate; Hydrogen Peroxide; Metronidazole; Tinidazole

Criteria

Enrollment criteria include:

1. Aged 18 years or older

2. Biological male

3. Uncircumcised

4. HIV seronegative

5. Willing to comply with the requirements of the protocol

6. No current sexually transmitted infection (N. gonorrhoeae or C. trachomatis)

7. No clinically relevant genital symptoms / signs