Effect of Antibiotic Choice On ReNal Outcomes (ACORN)
Status:
Enrolling by invitation
Trial end date:
2024-02-01
Target enrollment:
Participant gender:
Summary
Sepsis is one of the most common causes of acute illness and death in the United States.
Early, empiric broad-spectrum antibiotics are a mainstay of sepsis treatment. Two classes of
antibiotics with activity against Pseudomonas, anti-pseudomonal cephalosporins and
anti-pseudomonal penicillins, are commonly used for acutely ill adults with sepsis in current
practice. Recent observational studies, however, have raised concern that anti-pseudomonal
penicillins may cause renal toxicity. Anti-pseudomonal cephalosporins, by comparison, may be
associated with a risk of neurotoxicity. Rigorous, prospective data regarding the comparative
effectiveness and toxicity of these two classes of medications among acutely ill patients are
lacking. The investigator propose a randomized trial comparing the impact of anti-pseudomonal
cephalosporins and anti-pseudomonal penicillins on renal outcomes of acutely ill patients.