Effect of Anti-inflammatory and Anti-microbial Co-supplementations in Traumatic ICU Patients at High Risk of Sepsis
Status:
Completed
Trial end date:
2021-10-04
Target enrollment:
Participant gender:
Summary
The occurrence of sepsis in trauma patients is a very serious complication. Identifying
trauma patients at high risk of sepsis was not revealed in the latest surviving sepsis
campaign in 2016. Several biomarkers have been proposed for early prediction of sepsis in
trauma patients as leukocyte anti sedimentation rate (LAR) and the proinflammatory cytokine
monocyte chemo attractant protein-1 (MCP-1). Sepsis prophylaxis before occurrence of
multi-organ failure still represents a major challenge. Vitamin D and probiotics have
antimicrobial, anti-inflammatory and gut microbiota immune modulatory properties.Little is
known about the effect of vitamin D and probiotics co-supplementation on the inflammatory
response in trauma patients at high risk of sepsis.
Another promising strategy is the use of vitamin C in addition to thiamine. Trauma is
associated with increased oxidative stress and vitamin C deficiency. High dose vitamin C is
required to restore oxidant-antioxidant balance. Vitamin C and thiamine have shown promising
results in treatment of sepsis. Vitamin C possesses anti-inflammatory, endothelial protective
and anti-microbial effects. Thiamine is the precursor of thiamine pyrophosphate (TPP), a key
enzyme in Krebs cycle.