Effect of Antacids on Gleevec® in Healthy Volunteers
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
This is a research study that will investigate the effects of antacids (often used to treat
stomach upset) on Gleevec® (a drug that is FDA-approved to treat some types of cancer) in
healthy volunteers. Twelve healthy volunteers (six men and six women) will be recruited to
complete the study. This research study will compare Gleevec® in the body when taken with and
without antacids. Each volunteer will receive a 400 mg pill of Gleevec® on two occasions. One
one occasion they will take the dose of Gleevec® alone. On another occasion, they will take
the Gleevec® 15 minutes after taking a 20 mL dose of antacids. Several blood samples will be
drawn to measure the concentrations of Gleevec® and its breakdown products in the blood, with
and without the influence of antacids.