Effect of Angiotensin Receptor Blockade on Insulin Resistance and Adipose Tissue Cytokines in Type 2 Diabetes
Status:
Completed
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
The study aims to investigate the effect of acute angiotensin receptor blockade on insulin
action/insulin resistance and expressions of selected adipocytokines in subcutaneous adipose
tissue in insulin-resistant subjects with type 2 diabetes and healthy controls.
Hypothesis: Changes in adipocytokine concentrations and/or expressions and different
reactions to acute in vivo induced hyperinsulinemia and angiotensin receptor blockade will be
found in patients with type 2 diabetes compared to healthy subjects. A significant
relationships between insulin sensitivity and selected adipokines and intracellular fat
content and high energy phosphates in soleus muscle will be documented in healthy
individuals, while no significant relation will be found in patients with type 2 diabetes.