Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

One-lung ventilation during thoracic surgery may affect systemic oxygenation and peripheral microcirculation by hypoxic pulmonary vasoconstriction. Both intravenous and inhalational anesthetics can be used during one-lung ventilation. However, there is still a controversy which anesthetic would be more appropriate during one-lung ventilation in the perspective of oxygenation and microcirculation. The investigators hypothesized that intravenous and inhalational anesthetics may affect oxygenation and microcirculation differently during one-lung ventilation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Anesthetics; Desflurane; Isoflurane; Propofol

Criteria

Inclusion Criteria:

• undergoing thoracic surgery including one-lung ventilation

Exclusion Criteria:

• refuse to enroll

• BMI over 30 kg/m(2)

• severe obstructive or restrictive lung disease

• preoperative supplemental oxygen, intubated, or mechanical ventilatory support

• preoperative arterial partial pressure of oxygen < 60 mmHg

• pregnancy

• history of coronary artery disease

• preoperative continuous infusion of vasopressor or inotropes

• cannot undergo vascular occlusion test: anatomical abnormality of both arms, severe peripheral vascular disease, presence of A-V fistula