Effect of Anesthetics on Cardiac Biomarkers in Mitral and Aortic Valve Replacement/Plasty
Status:
Completed
Trial end date:
2023-01-09
Target enrollment:
Participant gender:
Summary
Abstract Cardiac troponin is one of the biomarkers of the heart, and its high level
correlates with a high risk of damage to cardiomyocytes.
Objective: To determine the effect of anesthetics on cardiac enzymes during mitral and aortic
valve replacement in adults.
methods. Single-center prospective randomized controlled clinical study. A total of 255
patients were assigned randomly into three groups according to the type of anesthesia: the
first group of 85 patients with propofol, the second group with sevoflurane - 85 patients,
and the last - 85 patients were with isoflurane.
Cardiac troponin I levels were calculated in ng/mL using the i-CHROMAII portable fluorescent
analyzer manufactured by BoditechMedInc. (South Korea). Normal range: <0.4 ng/mL. Cardiac
index (CI=CO/body surface area), oxygen consumption (VO2 = Cardiac index (CI)*AVD or VO2 = CO
× (CaO2 - CvO2) ~ CO × Hb × 1.34 × (SaO2 - SvO2) / 100) were determined before induction into
anesthesia.