Investigator' s study designed to investigate effect of general and regional anesthesia on
fracture healing.The 40 age and older ASAI-III patients who will operate due to femur
fracture (except femur neck fracture) will be enrolled in this study after informed consent
approval.
Subjects will be divided into two groups by a computerized randomization method. 40 patients
will be enrolled in this study. General anesthesia will perform for 20 patients. Regional
anesthesia will perform for 20 patients. Preoperative, 4. week and 12. weeks laboratory test
which include blood and urine β-C terminal telopeptid (β-CTX), blood alkaline phosphatase and
osteocalcin will test for all patients. All patients will not use nonsteroid
anti-inflammatory drugs during study neither perioperative nor postoperative periods.
fracture healing will be asses with clinical evaluation and laboratory tests.