Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation

• Status: Completed
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This prospective randomized study aims to investigate the effect of continuous versus interrupted use of Amiodarone on the procedure outcome in long-standing persistent (LSP) atrial fibrillation patients undergoing pulmonary vein antral isolation (PVAI).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Texas Cardiac Arrhythmia Research Foundation
• Collaborators: California Pacific Medical Center; Case Western Reserve University; Catholic University, Italy; Southlake Regional Health Centre; Stanford University; University of Kansas
• Treatments: Amiodarone

Criteria

Inclusion Criteria:

1. History of LSP AF

2. Age > 18 years

3. Willing and ability to understand and sign an informed consent

4. Patients on chronic Amiodarone therapy (≥ 3 months)

Exclusion Criteria:

1. Unstable angina

2. Concomitant treatment with other class I or III antiarrhythmic drugs

3. Myocardial infarction within past 3 months)

4. Presence of any disease that is likely to shorten life expectancy to < 1 year

5. Symptomatic heart failure, NYHA III or IV

6. Contraindications for Amiodarone

7. Chronic liver diseases

8. Pregnant or breast-feeding mothers