Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients
Status:
Not yet recruiting
Trial end date:
2026-08-31
Target enrollment:
Participant gender:
Summary
Lower serum bicarbonate levels, even within the normal laboratory range, in kidney transplant
recipients (KTRs) are associated with an increased risk of graft loss, cardiovascular events
and mortality. Because acid retention is common in KTRs, it is plausible that alkali therapy
in KTRs may also result in improved vascular and graft function. The investigators will
perform a randomized, double-blinded, placebo-controlled, 12 month study in 120 KTRs to
examine the effect of sodium bicarbonate therapy on surrogate markers of CVD and graft
function. The overall hypothesis is that treatment with bicarbonate will improve indicators
of vascular and graft function in KTRs by decreasing complement activation.
Phase:
Phase 4
Details
Lead Sponsor:
University of Colorado, Denver
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)