Effect of Acid Suppression Medication on Pediatric Microbiome
Status:
Unknown status
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
The colonic microbiome is essential in health and disease, and is highly dynamic during the
first several years of life. Proton pump inhibitors (PPIs) and histamine-2 receptor
antagonists (H2RAs) are widely used in children, but the effects of PPIs and H2RAs on the
pediatric colonic microbiome are unknown. This study will determine whether acid suppression
with these medications affects the microbiome of otherwise healthy children who are
prescribed acid suppression for gastroesophageal reflux disease (GERD), and determine the
duration and magnitude of microbiome changes.