Traditionally, beta blockers have been used for migraine prophylaxis, but in later years also
antiepileptic drugs. Contraindications and side effects have to some degree limited their
use, and new prophylactics that can be used by most migraine sufferers and with little side
effects are in demand. One product that may seem to fulfill these requirements is
Acetyl-L-carnitine, which is a dietary supplement and naturally occurs in plants and animals.
L-carnitine is necessary for fatty-acid metabolism and energy production.
To our knowledge, no placebo-controlled studies have previously evaluated the efficacy of
Acetyl-L-carnitine in adults with migraine.
The aims of the present study is to evaluate the efficacy of Acetyl-L-carnitine as a
prophylaxis in migraine patients