Overview

Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude

Status:
Active, not recruiting
Trial end date:
2020-12-31
Target enrollment:
0
Participant gender:
All
Summary
Randomized, placebo controlled trial evaluating efficacy of acetazolamide on right heart function during exercise in lowlanders older than 40 years travelling from 760 m to 3'100 m.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of Zurich
Collaborator:
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Treatments:
Acetazolamide
Criteria
Inclusion Criteria:

- Healthy men and women, age 40-75 yrs, without any disease and need of medication.

- Born, raised and currently living at low altitude (<800m).

- Written informed consent.

- Kyrgyz ethnicity

Exclusion Criteria:

- Any active respiratory, cardiovascular or other disease requiring regular treatment or
being otherwise relevant for tolerance of hypoxia or altitude exposure.

- Any condition that may interfere with protocol compliance including current heavy
smoking (>20 cigarettes per day or >20 pack-years with active smoking during the last
10 years), regular use of alcohol.

- Allergy to acetazolamide and other sulfonamides.