Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Acetazolamide improves central sleep apnea related to opium consumption.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shahid Beheshti University of Medical Sciences
• Collaborator: Masih Daneshvari Hospital
• Treatments: Acetazolamide; Opium

Criteria

Inclusion Criteria:

• Opium or opioid use for at least two months in a daily manner

• Presence of five or more central sleep apnea per hour in a full-night recorded PSG

Exclusion Criteria:

• Congestive heart failure

• living in high altitude

• Chronic Obstructive Pulmonary Disease (COPD)

• Carbon dioxide partial pressure (pCO2) elevation due to other respiratory diseases

• Body Mass Index (BMI) > 32

• Obesity Hypoventilation Syndrome

• Severe renal or liver disorders

• Using Benzodiazepine

• Using Theophylline